Signs of infection (increasing redness, warmth, swelling, or pus) require immediate discontinuation and medical evaluation
All data were fitted to the standard 1:1 binding model
In LUKE Health, this is implemented with dual-layer PostgreSQL triggers: Layer 1: A database trigger on the orders table checks for an active, non-expired prescription matching the compound being ordered Layer 2: A constraint trigger verifies the prescribing provider's license is valid for the patient's state This isn't application logic that a developer might accidentally bypass during a feature update
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Exclusion volumes primarily aim to boost specificity and selectivity of pharmacophore models by narrowing the search space, thereby minimizing false positives resulting from improper ligand positioning
